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Towards elucidating

My scientific goal as a structural biologist is to reveal the molecular choreography at atomic resolution, to unveil the physiological and cellular processes involving membrane transport (including cellular uptake of glucose, generation of action potential, and excitation-contraction coupling of muscles).In the past five years, my laboratory has made significant progress towards elucidating the structures of human glucose transporters (GLUTs) and various eukaryotic voltage-gated sodium and calcium channels (Na).In detail, CD spectroscopy as well as ESI-MS and MS2 techniques were applied to gain an overall picture of the binding properties of this class of (O, S) bidentate Pt(II) compounds with defined oligonucleotide sequences in single strand, duplex or G-quadruplex form, as well as with the nucleobase 9-methylguanine.On the whole, it was demonstrated that the tested compounds interact with DNA and produce conformational changes of different extents depending on the sequence and structure of the examined oligonucleotide.This site uses cookies to improve performance by remembering that you are logged in when you go from page to page.To provide access without cookies would require the site to create a new session for every page you visit, which slows the system down to an unacceptable level.Many metazoans ranging from sea anemones to aquatic vertebrates have been observed to release chemical cues upon mechanical injury triggering complex sets of innate behavioral modules in others.One of the first reports of such a phenomenon was by Karl von Frisch in 1938, who made these observations in freshwater fishes.

Allowing a website to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Google(); req('single_work'); $('.js-splash-single-step-signup-download-button').one('click', function(e){ req_and_ready('single_work', function() ); new c. For many organisms, serious injury or death of a companion is a warning sign of danger or predators.Guanine was established as the preferential target within the DNA sequence, but in the absence or unavailability of guanines, alternative binding sites can be addressed.The implications of these results are thoroughly discussed.

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